Crystal structure of bee-venom phospholipase A2: correction.
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منابع مشابه
Crystal structure of bee-venom phospholipase A2 in a complex with a transition-state analogue.
The 2.0 angstroms crystal structure of a complex containing bee-venom phospholipase A2 (PLA2) and a phosphonate transition-state analogue was solved by multiple isomorphous replacement. The electron-density map is sufficiently detailed to visualize the proximal sugars of the enzyme's N-linked carbohydrate and a single molecule of the transition-state analogue bound ot its active center. Althoug...
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The crystal structure of a complex between a phosphonate transition-state analogue and the phospholipase A2 (PLA2) from Naja naja atra venom has been solved and refined to a resolution of 2.0 angstroms. The identical stereochemistry of the two complexes that comprise the crystal's asymmetric unit indicates both the manner in which the transition state is stabilized and how the hydrophobic fatty...
متن کاملThe correlation between anti phospholipase A2 specific IgE and clinical symptoms after a bee sting in beekeepers
INTRODUCTION Beekeepers are a group of people with high exposure to honeybee stings and with a very high risk of allergy to bee venom. Therefore, they are a proper population to study the correlations between clinical symptoms and results of diagnostic tests. AIM The primary aim of our study was to assess the correlations between total IgE, venom- and phospholipase A2-specific IgE and clinica...
متن کاملBee Venom Phospholipase A2: Yesterday’s Enemy Becomes Today’s Friend
Bee venom therapy has been used to treat immune-related diseases such as arthritis for a long time. Recently, it has revealed that group III secretory phospholipase A2 from bee venom (bee venom group III sPLA2) has in vitro and in vivo immunomodulatory effects. A growing number of reports have demonstrated the therapeutic effects of bee venom group III sPLA2. Notably, new experimental data have...
متن کاملLocalization of structural elements of bee venom phospholipase A2 involved in N-type receptor binding and neurotoxicity.
We have shown previously that neurotoxic venom secretory phospholipases A2 (sPLA2s) have specific receptors in brain membranes called N-type receptors that are likely to play a role in the molecular events leading to neurotoxicity of these proteins. The sPLA2 found in honey bee venom is neurotoxic and binds to this receptor with high affinity. In this paper, we have used a number of mutants of ...
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عنوان ژورنال:
- Science
دوره 252 5007 شماره
صفحات -
تاریخ انتشار 1991